Relationshipsbetweenmetabolicprofile,hypertensionanduricacidwithcardiometabolicriskinadolescentswithabdominalobesity:impactofgeodemographicfactorsontheprevalenceofabdominalobesity

Abstract

Background:Association of hyperuricemia, dyslipidemia and high blood pressure (BP) among adolescentswith high waist-to-height ratio (WHtR) remains not fully addressed and could represent a new way to diagnoseadolescents early with cardiometabolic risk.Objective:We aimed to determine abdominal obesity (AO) prevalence and investigate relations between AO,uric acid (UA), lipid profiles, BP and geographical patterns in adolescents.Subjects:577 and 204 Algerian students aged between 10 and 19 years were included in our epidemiologicaland biochemical studies, respectively.Methods:Height, weight, waist circumference (Wc) and hip circumferences, body mass index (BMI) and BPwere measured. Fasting blood sampling was performed to measure glycemia, lipid profile, uricemia, insuline-mia and leptinemia. The WHtR≥0.50 was applied for the diagnosis of AO and geodemographics was evaluated.Results:The prevalence of AO was 12.13% among all students, 19.17% and 16.39% among students livingin urban and plain areas, respectively. The risk of AO may be reduced in rural and mountainous areas. Lipidparameters, UA, insulin and leptin serum concentrations were significantly increased in adolescents with WHtR≥0.50 compared to those with WHtR <0.50. Cardiometabolic risk was increased with WHtR≥0.50 and BMI >26.Means of BMI, Wc, BP, and lipid parameters were significantly increased in the fourth quartiles compared tothe first quartile of UA.Conclusion:Urban areas and plains represent factors contributing to AO and WHtR≥0.50 may be used as acut-off point to define risks of high BP, lipid abnormalities and UA serum level in Algerian adolescents.