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dc.contributor.authorAit-Tahar, Kamel-
dc.contributor.authorP. Liggins, Amanda-
dc.contributor.authorP. Collins, Graham-
dc.contributor.authorCampbell, Andrew .......-
dc.date.accessioned2020-12-01T08:54:53Z-
dc.date.available2020-12-01T08:54:53Z-
dc.date.issued2009-07-29-
dc.identifier.urihttp://dspace.univ-bouira.dz:8080/jspui/handle/123456789/10619-
dc.description.abstractThe identification of immunogenic cancer testis antigens (CTAs) as immunotherapeutic targets represents one approach to improve treatment options for diffuse large B‐cell lymphoma (DLBCL). We previously identified PASD1 [PAS (Per ARNT Sim) domain containing 1 (PASD1)], a DLBCL‐associated CTA that was expressed in a range of hematopoietic malignancies. The aim of the present study was to investigate the presence of a cytotoxic T‐cell (CTL) response to PASD1 in DLBCL patients. A significant γ‐interferon (IFN) release was detected in 21/29 HLA‐A*0201‐positive DLBCL patients (18 de novo DLBCL, two transformed DLBCL and one T‐cell rich B‐cell lymphoma) following short‐term culture of their peripheral blood mononuclear cells stimulated with five HLA‐A*0201‐restricted PASD1 peptides. No significant responses were detected in 21 HLA‐A*0201‐negative DLBCL patients (12 de novo DLBCL, seven transformed DLBCL, two T‐cell rich B‐cell lymphoma) or six normal subjects. CTL cell lines were able to lyse PASD1‐positive tumour cells in a major histocompatibility complex‐Class I dependent manner. The presence of a γ‐IFN response correlated with PASD1 protein expression in the tumour cells in 12/15 cases studied. This is the first report of a CTL response to a CTA in DLBCL. Our results provide additional valuable evidence supporting PASD1 as a potential immunotherapeutic target for the treatment of DLBCL and other malignancies.en_US
dc.language.isoenen_US
dc.publisherUniversité Akli Mouhand Oulhadj-Bouiraen_US
dc.subjectcancer testis antigen cytotoxic T‐cell diffuse large B‐cell lymphoma immunotherapy lymphomaen_US
dc.titleCytolytic T-cell response to the PASD1 cancer testis antigenin patients with diffuse large B-cell lymphomaen_US
dc.typeArticleen_US
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