Please use this identifier to cite or link to this item: http://dspace.univ-bouira.dz:8080/jspui/handle/123456789/16413
Title: Changes in the NFjB and E-cadherin expression are associated to diabetic nephropathy in Psammomys obesus
Authors: Aroune, Djamila
Libdiri, Farid
Leboucher, Sophie
Maouche, Boubekeur
Marco, Sergio
El-Aoufi, Salima
Keywords: Diabetic nephropathy
Psammomys obesus;
Nuclear factor kB (NFjB)
E-cadherin
Inflammation
High energy diet
Issue Date: 2016
Publisher: Université Akli Mohend Oulhadj Bouira
Citation: Université Akli Mohend Oulhadj Bouira
Abstract: Diabetes mellitus is a major leading cause of end-stage renal failure, characterized by kidney inflammation and glomerular dysfunction, in worldwide. Kidney inflammation is associated to modifications in the expression levels of pro-inflammatory molecules, such as nuclear factor-jB (NFjB) and adhesion molecules, such as E-cadherin, leading to glomerular dysfunction. However, the relationships between these two processes in human diabetic nephropathy remain an open question. Since Psammomys obesus is an ideal animal model to study diabetes mellitus temporal evolution, we have used this model to study the correlation between kidney structural changes and modification on the expression levels of NFjB and E-cadherin over time. We have demonstrated that, after induction of diabetes metillus with a high energy diet (HED), P. obesus develops the characteristic symptoms of human disease. In detail, at the third month nuclear factor NFjB is expressed in the kidney of diabetic P. obesus and structural renal changes, such as mesangial expansion or interstitial fibrosis, are detectable; at 6 months, thickening of glomerular basement membrane, glomerular sclerosis, and tubular atrophy occurs; at 9 months, symptoms of the final
URI: http://dspace.univ-bouira.dz:8080/jspui/handle/123456789/16413
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