Veuillez utiliser cette adresse pour citer ce document : http://dspace.univ-bouira.dz:8080/jspui/handle/123456789/16413
Affichage complet
Élément Dublin CoreValeurLangue
dc.contributor.authorAroune, Djamila-
dc.contributor.authorLibdiri, Farid-
dc.contributor.authorLeboucher, Sophie-
dc.contributor.authorMaouche, Boubekeur-
dc.contributor.authorMarco, Sergio-
dc.contributor.authorEl-Aoufi, Salima-
dc.date.accessioned2024-03-17T09:53:40Z-
dc.date.available2024-03-17T09:53:40Z-
dc.date.issued2016-
dc.identifier.citationUniversité Akli Mohend Oulhadj Bouiraen_US
dc.identifier.urihttp://dspace.univ-bouira.dz:8080/jspui/handle/123456789/16413-
dc.description.abstractDiabetes mellitus is a major leading cause of end-stage renal failure, characterized by kidney inflammation and glomerular dysfunction, in worldwide. Kidney inflammation is associated to modifications in the expression levels of pro-inflammatory molecules, such as nuclear factor-jB (NFjB) and adhesion molecules, such as E-cadherin, leading to glomerular dysfunction. However, the relationships between these two processes in human diabetic nephropathy remain an open question. Since Psammomys obesus is an ideal animal model to study diabetes mellitus temporal evolution, we have used this model to study the correlation between kidney structural changes and modification on the expression levels of NFjB and E-cadherin over time. We have demonstrated that, after induction of diabetes metillus with a high energy diet (HED), P. obesus develops the characteristic symptoms of human disease. In detail, at the third month nuclear factor NFjB is expressed in the kidney of diabetic P. obesus and structural renal changes, such as mesangial expansion or interstitial fibrosis, are detectable; at 6 months, thickening of glomerular basement membrane, glomerular sclerosis, and tubular atrophy occurs; at 9 months, symptoms of the finalen_US
dc.language.isoenen_US
dc.publisherUniversité Akli Mohend Oulhadj Bouiraen_US
dc.subjectDiabetic nephropathyen_US
dc.subjectPsammomys obesus;en_US
dc.subjectNuclear factor kB (NFjB)en_US
dc.subjectE-cadherinen_US
dc.subjectInflammationen_US
dc.subjectHigh energy dieten_US
dc.titleChanges in the NFjB and E-cadherin expression are associated to diabetic nephropathy in Psammomys obesusen_US
dc.typeArticleen_US
Collection(s) :Articles

Fichier(s) constituant ce document :
Fichier Description TailleFormat 
Changes in the NFjB and E-cadherin expression.pdf3,56 MBUnknownVoir/Ouvrir


Tous les documents dans DSpace sont protégés par copyright, avec tous droits réservés.