Anticancer activity of chemically prepared shrimp low molecular weight chitin evaluation with the human monocyte leukaemia cell line, THP-1

Abstract

In the present study, anticancer activities of chitin, chitosan and low molecular weight chitin were evalu- ated using a human tumour cell line, THP-1. A molecular weight–activity relationship and an electrostatic interaction–activity relationship were determined. The cytotoxic effects of chitin and derivatives were also evaluated using a normal human foetal lung fibroblastic cell line, MRC-5 and the specific cytotox- icity of chitin and derivatives to tumour cell lines was demonstrated. The high antitumour effect of low molecular weight of chitin was established.