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Title: | Comparative proteome profiling of hydatid fluid from Algerian patients reveals cyst location-related variation in Echinococcus granulosus |
Authors: | Zeghir-Bouteldja, Razika Polomé, Andy Bousbata, Sabrina Touil-Boukoffa, Chafia |
Keywords: | Echinococcus granulosus Hydatid fluid proteomics Anatomical location Fertility Antigen |
Issue Date: | 1-Jul-2017 |
Publisher: | Université de Bouira |
Citation: | Acta tropica Volume 171 Pages 199-206 |
Abstract: | Human cystic echinococcosis, an endemic zoonosis in Algeria, is caused by larvae of the cestode Echinococcus granulosus. Parasitic modulation of the immune response allows E. granulosus to persist in intermediate hosts. Previous in vitro and in vivo immunological studies have shown differences in host immune responses according to the status and location of the hydatid cysts in the body. In this study, a proteomic analysis of human hydatid fluids was performed to identify the proteins in hydatid cyst fluids. Hydatid fluid was obtained after cystic surgical removal from three patients with these cysts. The study was conducted on fertile hydatid fluids from lungs, vertebra, and infertile paravertebral fluids. Comparisons of the protein compositions of these fluids revealed differences in their protein profiles. These differences are probably related to the cyst location and fertility status of the parasite. Notably, our analysis … |
URI: | http://dspace.univ-bouira.dz:8080/jspui/handle/123456789/9497 |
Appears in Collections: | Articles |
Files in This Item:
File | Description | Size | Format | |
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Comparative proteome profiling of hydatid fluid from Algerian patients.pdf | 432,46 kB | Adobe PDF | View/Open |
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